| Title | [Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities] | | Author(s) | Shi LH, Jin DZ, Zhou WC, Wang J, Chen XH | | Institution | State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China. shilihong6@hotmail.com | | Source | Yao Xue Xue Bao 2009 Jul; 44(7):747-53. | | Abstract | Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxities. | | Language | chi | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 19806914 |
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